PostgreSQL es una base de datos relacional de código abierto y es adecuada para aplicaciones más grandes y complejas. Puedes usar la extensión psycopg2 para conectarte a PostgreSQL en python usando Flask.
pip install psycopg2
from flask import Flask
import psycopg2
app = Flask(__name__)
# Configurar la conexión a PostgreSQL
app.config['DATABASE_URL'] = 'postgresql://usuario:contraseña@localhost/mi_basededatos'
conn = psycopg2.connect(app.config['DATABASE_URL'])
@app.route('/')
def index():
cursor = conn.cursor()
cursor.execute('SELECT * FROM tabla')
resultados = cursor.fetchall()
conn.close()
return str(resultados)
if __name__ == '__main__':
app.run()

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